The HPE ProLiant DL385 Gen11 is a 2U dual-processor (2P) server delivering strong compute performance, faster data transfer, and expanded memory depth at full 2P capability. Powered by 4th and 5th Generation AMD EPYC 9004 and 9005 Series processors with up to 160 cores, it offers increased memory bandwidth, high-speed PCIe Gen5 I/O, enhanced GPU support, and EDSFF storage — making it a standout, accelerator-optimized enterprise server solution.

8LFF
P53925-B21

8SFF
P53921-B21

48SFF
P57844-B21

12EDSFF
P53929-B21

GPU - P54198-B21

To support Double Wide or Single Wide GPUs, the DL385 Gen11 GPU CTO Server must be selected. GPUs cannot be supported in rear PCIe slots for DL385 Gen11.

4x DW or 8x SW GPUs Supported

8LFF CTO (P53925-B21)

Front 4LFF
P55089-B21

Mid-Tray 4LFF
P55085-B21

Rear 4LFF
P55088-B21

2SFF Side by Side
P55093-B21

8 LFF Notes

• The 8 LFF Chassis also supports 2 SFF Stacking Drives (P55091-B21)
• The 4 LFF rear drive box will consume space for the primary, secondary and tertiary risers.
• The 12 LFF configuration needs to be built up with 8LFF chassis and one 4LFF drive cage
• CPU TDP above 300W then Mid Cage cannot be selected
• HPE DL385 G11 x16 Prim FIO Riser LFF Rear (P55098-B21) selectable when rear 4LFF SAS/SATA cage kit (P55088-B21) is configured.

8SFF CTO (P53921-B21)

8SFF Front Tri-mode

• P55082-B21 - U.3 x1 BC
• P55083-B21 - U.3 x4 BC

8SFF Mid Tray Tri-Mode

• P55086-B21 - U.3 x1
• P55087-B21 - U.3 x4

2SFF Stacked
P55091-B21

• P57857-B21 - Universal Media Bay Kit

8 SFF Notes

• If Front 8SFF Drive cage is selected quantity above one then SFF Backplane Power Cable Kit must be selected.
• U.3 x1 and U.3 x4 drive cages can mix.
• 3x 8 SFF drive cages can be used to build up a 24 SFF configuration.
• The Universal Media Bay (P57857-B21) can only be populated in Box 1.
• CPU TDP above 300W then Mid Cage cannot be selected

GPU CTO (P54198-B21)

8SFF U.3
P57867-B21

EDSFF
P62355-B21

2U Standard
P58458-B21

TDP less than 240W

2U Performance
P58459-B21

TDP above 240W and below 300W

Max Performance 2U
P58460-B21

Mid tray installed, and Less than 300w

Cooling Notes

• Above 300W then Mid Cage cannot be selected
• When Maximum Performance 2U Heat Sink Kit is selected, Hi-Perf Air Baffle Kit is required.
• When Standard or Performance 2U Heat Sink Kit is selected, Standard/Perf Air Baffle Kit is required.

DLC from PCIe
P62035-B21

DLC from NS204i-u
P62032-B21

55cm Quick Disconnect
P62042-B21

450mm Quick Disconnect
P62046-B21

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• NOTE: Just the DLC; you still need to riser and NS204u-i if desired.
• Seven (7) performance fan kits are required.
• 450mm Quick Disconnect for GPU-optimized server.
• 55cm Quick Disconnect for non-GPU-optimized configuration

2U Standard Fan Kit
P58464-B21

2U Performance Fan Kit
P58465-B21

2U Standard/Performance Air Baffle Kit
P57886-B21

2U High Performance Air Baffle Kit
P57887-B21

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• Air Baffles cannot be configured if mid cages are configured.
• When Standard or Performance 2U Heat Sink Kit is selected, Standard/Perf Air Baffle Kit is required.
• When Maximum Performance 2U Heat Sink Kit is selected, Hi-Perf Air Baffle Kit is required
• If DLC Module is selected then Performance Fan kit must be selected.
• supports up to 6 fans with fan redundancy built in
• 256 GB DIMM requires quantity of six of Performance Fans

NS204i-u Boot Device

The NS204i-U functions as a dedicated boot device module rather than a PCIe card, with externally accessible M.2 drives. It ships with 2x 480GB M.2 NVMe SSDs and supports RAID 1. Three mounting locations are available for the module, though PCIe slot availability may be reduced depending on placement.

• Positioning in the tertiary location above the power supplies means tertiary risers are not supported.
• Placement in secondary Slot 4 means Slot 4 and Slot 5 of the secondary riser cage are unavailable.
• Selecting the low-profile secondary riser places the module below the 4LFF rear drive cage, with only one riser supported in that secondary location.

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P48183-B21 | v1 for AMD 4th Gen
P78279-B21 | v2 for AMD 5th Gen

NS204i-u Options

Secondary Slot 4
P57885-B21

Rear 4 LFF Not Supported

P57891-B21 Riser Not Supported

Secondary + Rear 4LFF
P57885-B21

Supported Rear 4 LFF

Not Supported P57891-B21

Cable Kit P57013-B21 Required w/ Rear 4LFF

Tertiary
P57850-B21

Only 1 Tertiary riser kit can be selected

Supports Stacked Drives (P55091-B21) in the 8LFF & 8SFF Chassis

Rear 4LFF not Supported

The MR (MegaRAID) and SR (SmartRAID) controller series use different configuration tools and cannot be mixed as internal controllers in the same server. Both series support SAS, SATA, and NVMe drives when paired with a tri-mode U.3 backplane, allowing mixed-drive configurations. The server has no embedded software RAID support — direct-attached SATA drives operate in AHCI mode only, so a hardware storage controller is required for any RAID functionality.

SR Series (SmartRAID)

SR Series
Installation Service Manual

The SR series represents the high-end controller lineup, offered exclusively in the Type-p PCIe form factor.

This is the preferred option for high drive-count builds or maximum storage throughput, and like the cached MR controllers, it requires a battery or capacitor for cache protection.

MR Series (MegaRAID) - View PDF

MR Series
Installation Service Manual

The MR series offers a broader, more flexible controller lineup, available in both Type-o and Type-p form factors.

Cached models — MR408i-o, MR416i-o, and MR416i-p — add Flash-Backed Write Cache (FBWC) support.

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Choosing Between MR and SR

• Need OCP slot deployment → MR type-o only
• Simple RAID, no cache needed → MR216i-o or MR216i-p
• Need cache, moderate drive count → MR408i-o or MR416i-o/p
• Maximum drive count or throughput → SR932i-p
• External SAS/SATA storage → E208e-p (Gen10, type-p, external only)

The OCP slots are not the same.
Slot 21 does not have any connection to the drives; this is why Slot 22 supports a Type-O Storage controller.
When installing a single OCP NIC, install it in Slot 21.

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OCP Slot 21

Form Factor: OCP PCIe 5.0 x8

Supports Type-o storage controller and OCP NIC 3.0 adapter

x16 Upgrade Kit: P57882-B21 (OCP Slot 21 x16 upgrade)

• Required if below are selected:
• Broadcom BCM57504 10/25GbE 4-port (P26269-B21)
• Intel E810 100GbE (P22767-B21)

OCP Slot 22

Form Factor: OCP PCIe 5.0 x8

Supports OCP NIC 3.0 adapter only

Does not support Type-o storage controllers

When installing a single OCP NIC, HPE recommends using Slot 22.

Default

8LFF CTO | 1x16 Slots 3

8SFF CTO | 1x16 Slots 3

12 EDSFF CTO | 1x16 Slots 3

48SFF CTO | 2x16 Slots 3 & 6

GPU CTO | 2x16 Slots 3 & 6

2x16 Primary
P57890-B21

This provides Slot1 and Slot 2 in the Primary position.

Cannot be selected if 4LFF rear cage is selected.

Secondary Slot 6
P55097-B21

This provides Slot 6 in the Secondary position.

This requires the 2nd processor.

This riser kit is required to select the 2x16 Secondary Riser Upgrade Kit.

Secondary Slot 4 & 5
P57891-B21

This provides Slot 4 and Slot 5 in the Secondary position.

This requires the 2nd processor.

The (P55097-B21) Secondary Riser Kit is required.

This riser kit cannot be supported with P57849-B21 x16 OCP1 OCP2 2P Upgrade Kit.

Secondary Slot 5
P68392-B21

This provides Slot 5 in the Secondary position.

This requires the 2nd processor.

This riser provides the 3rd PCIe slot for the GPU CTO Server.

Supported with P57849-B21 x16 OCP1 OCP2 2P Upgrade Kit.

Secondary 3x16
P65830-B21

This is a NEBS compliant riser kit for Telco customers’ requirements.

This provides Slots 4, 5, 6 in the Secondary position.

Tertiary
P57893-B21

This provides Slot 7 and Slot 8 in the Tertiary position

This requires the 2nd processor

Tertiary NEBS-compliant
P65833-B21

This provides Slot 7 and Slot 8 in the Tertiary position

This is a NEBS compliant riser kit for Telco customers’ requirements.

2SFF Stacked
P55091-B21

Provides 2SFF Drives

4LFF Primary FH
P55098-B21

This provides one Primary riser positioned below the 4LFF rear cage when it is configured

When the 4LFF rear cage is configured, only one Primary riser is supported.

4LFF Secondary FH
P57892-B21

This provides one Secondary riser positioned below the 4LFF rear cage when it is configured.

When the 4LFF rear cage is configured, only one Secondary riser is supported.

4LFF Secondary LP
P59260-B21

This provides one Secondary riser positioned below the 4LFF rear cage when it is configured

This riser kit is required when NS204i-u NVMe Boot Device is selected along with 4LFF rear cage selection.